299 papers
Cancer biology explores the complex ways cells grow out of control, investigating the genetic mutations and environmental factors that drive tumor formation. This field seeks to understand how healthy cells transform into malignant ones and how these rogue cells spread throughout the body. By decoding these fundamental mechanisms, researchers aim to develop more effective treatments that target the disease at its source while sparing healthy tissue.
At Gist.Science, we process every new preprint published in this category directly from bioRxiv to ensure you stay ahead of the curve. Our team provides both accessible plain-language overviews and detailed technical summaries for each study, bridging the gap between raw research data and practical understanding. Whether you are a specialist or a curious reader, our goal is to make these critical findings clear and actionable.
Below are the latest papers in cancer biology, offering fresh insights into the ongoing fight against this disease.
This paper establishes a benchmarking framework for comparing mouse neoantigen immunogenicity by demonstrating that experimental peptide-MHC complex stability () is a superior predictor of in vivo T cell responses than in silico binding affinity predictions.
This study identifies that NINJ2 maintains lysosomal membrane integrity by interacting with LAMP1, thereby preventing the leakage of labile iron and the degradation of ferritin, a mechanism that protects cells from ferroptosis and presents a potential therapeutic target for iron-addicted cancers.
By employing cross-species graph-embedding on age-stratified murine PDAC models, this study reveals that ageing shapes a distinct inflammatory microenvironment driving malignant cell biology and uncovers IRAK4 as a specific therapeutic vulnerability in aged pancreatic cancer that is missed in younger models.
This study demonstrates that clove aqueous extract suppresses patient-derived ovarian cancer cells by triggering a multi-organellar stress crisis characterized by lysosomal destabilization and mitochondrial hyperpolarization, which collectively induce a bioenergetic failure and cell death.
This study utilized ImageTwin-AI to investigate whether charging for corrections in the Journal of Cancer discouraged pre-publication image data scrutiny, finding that while the removal of such fees in 2025 coincided with a modest decrease in problematic images (from 20.3% to 15.9%), the policy change had only a limited impact on pre-publication handling.
This study demonstrates that sanguinarine induces p53-dependent apoptosis in the *C. elegans* germline by elevating reactive oxygen species, which subsequently activate the ATM/ATR-mediated CHK-1 DNA damage signaling pathway.
This study utilizes multimodal functional genomics to map drug-specific on-target resistance mechanisms for clinical WRN inhibitors in microsatellite-unstable cancers and identifies synthetic vulnerabilities, such as NHEJ factors and WIP1, to guide resistance-aware therapeutic strategies.
This study reveals that mammalian neuraminidase-1 (NEU1) acts as a critical regulator of platelet-derived thromboxane A2-mediated T-cell immunosuppression and tumor progression, explaining the comparable clinical efficacy of both aspirin and celecoxib in treating PIK3CA-mutant colorectal cancer by inhibiting NEU1 activity and preserving T-cell function.
By applying spatial profiling to over 300 histological domains in primary cutaneous melanoma, this study reveals that tumor cell dedifferentiation and plasticity are driven by complex, non-stochastic spatial interactions with immune cells and perivascular environments, which collectively map disease progression onto a landscape defined by MITF activity and neural crest-like phenotypes.